"Effect of betaine on s-adenosylmethionine levels in the cerebrospinal fluid in a patient with methylenetetrahydrofolate reductase deficiency and peripheral neuropathy" J Inherited Metabolic Disease 17(5): 560-5, 1994 "Disordered methionine/homocysteine metabolism in premature vascular disease," Arteriosclerosis and Thrombosis 13(9): 1253-60, 1993 Its occurrence, cofactor therapy and enzymology," Arteriosclerosis and Thrombosis 13(9): 1253-60, 1993 "Disordered methionine/homocysteine metabolism in premature vascular disease.
The usual TMG dose is 500 to 1,000mg per day – roughly equivalent to what a diet high in broccoli, spinach or beets would provide. Folic acid appears to help neutralize this effect at one or two 800mcg tablets. TMG supplementation may sometimes produce hyperactivity in autistic children.
Cardiovascular: Reduces cholesterol and triglyceride levels, helps eliminate hypoxia, improves coronary circulation, decreases angina pain.Viral/ bacterial infections: Enhances immune response.Immune modulation: Improves antibody response, enhances B- and T-cell function, and regulates cytokines.In a broad sense, TMG protects the body from many forms of physical, metabolic and environmental stress. DMG (TMG's metabolite) has been used as a nutritional supplement for over 25 years. It aids the body in overcoming a number of adverse health conditions, and is an intricate part of human metabolism. TMG is a versatile nutrient and provides an intermediary metabolite that can enable a person or animal to function at more optimum mental and physical levels. TMG lowers homocysteine levels with and without vitamins B12, B6 and folic acid.Īlong with cofactors such as vitamins B6, B12 and Folic Acid, TMG is part of a chemical contingent in the body that works against cancer, heart and neurological diseases, and nearly every age-related disorder. In one study, daily treatment with TMG, folic acid and choline normalized homocysteine levels in 17 of 19 patients. Multiple studies have demonstrated that medium to high levels of plasma homocysteine are associated with increased risk of heart disease, cerebrovascular disease and peripheral artery disease. Factors that decrease methylation include smoking, alcohol consumption, high fat diets and birth control pills. It may improve health, reduce the risk of genetically induced cancers, and slow cellular aging. SAMe then acts as a methyl donor for DNA: when attached to DNA, methyl groups appear protective, preventing mutated genes from expressing themselves. When methylation is working properly, homocysteine is quickly converted back to methionine which is then converted to SAMe (S-adenosylmethionine), which protects the liver and is a natural antidepressant.
In the liver, TMG transfers one of its three methyl groups to homocysteine, which is then converted into the useful amino acid methionine. NOTE: An inexpensive variety is Betaine HCL which acts as a stomach acidifier and is not practical due to stomach irritation at the doses required to enhance methylation metabolism. TMG is in available in powdered form, and is found in many over-the-counter preparations in health food stores. Methylation reactions and how they relate to the prevention of many diseases such as cancer, heart disease, liver disease and neurological disorders are a growing area of interest for researchers. Hyland et al reported increased SAM concentrations to near normal in a patient suffering from 5,10-methylenetetrahydrofolate reductase (an enzyme involved in the regeneration of methionine) deficiency where initial SAM concentration were undetectable. Animal studies have demonstrated that supplementary intake of betaine had a 2- to 5-fold increase in SAM concentrations. Betaine may influence neurological function indirectly via 5-adenosylmethionine synthesis. Through methyl transfers, betaine is derived from choline and subsequent reactions convert betaine to dimethylglycine. TMG is a byproduct of sugar beet processing and is a known methyl donor. learn what you should be doing right now.have a doctor review your case (optional).
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